Publications Scientifiques

2010

 

Breton E, Goetz C, Kintz J, Accart N, Aubertin G, Grellier B, Erbs P, Rooke R, Constantinesco A, Choquet P.  
In vivo preclinical low field MRI monitoring of tumor growth following a suicide gene therapy in an orthotopic mice model of human glioblastoma.
C R Biol : Comptes rendus biologie 2010 March ; 333(3):220-5 >>>READ MORE on


Dias JD, Liikanen I, Guse K, Foloppe J, Sloniecka M, Diaconu I, Rantanen V, Eriksson M, Hakkarainen T, Lusky M, Erbs P, Escutenaire S, Kanerva A, Pesonen S, Cerullo V, Hemminki
Targeted chemotherapy for head and neck cancer with a chimeric oncolytic adenovirus coding for bifunctional suicide protein FCU1.
Clinical Cancer Research. 2010 May 1;16(9):2540-9. >>>READ MORE on


Dummer R, Eichmüller S, Gellrich S, Assaf C, Dreno B, Schiller M, Dereure O, Baudard M, Bagot M, Khammari A, Bleuzen P, Bataille V, Derbij A, Wiedemann N, Waterboer T, Lusky M, Acres B, Urosevic-Maiwald M.
Phase II clinical trial of intratumoral application of TG1042 (adenovirus-interferon-gamma) in patients with advanced cutaneous T-cell lymphomas and multilesional cutaneous B-cell lymphomas.
Molecular Therapy. 2010 June 18;(6):1244-7. >>>READ MORE on


Hegge JO, Wooddell CI, Zhang G, Hagstrom JE, Braun S, Huss T, Sebestyén MG, Emborg ME, Wolff JA.
Evaluation of Hydrodynamic Limb Vein Injections in Nonhuman Primates.
Human Gene Therapy. 2010 May 17. [E.publication ahead of print] >>>READ MORE on


Wooddell CI, Zhang G, Griffin JB, Hegge JO, Huss T, Wolff JA.
Use of Evans blue dye to compare limb muscles in exercised young and old mdx mice.
Muscle & Nerve. 2010 April; 41(4):487-99. >>>READ MORE on


Zhang G, Wooddell CI, Hegge JO, Griffin JB, Huss T, Braun S, Wolff JA
Functional efficacy of dystrophin expression from plasmids delivered to mdx mice by hydrodynamic limb vein injection.
Human Gene Therapy. 2010 February; 21(2):221-37. >>>READ MORE on

2009

Dreicer R, Stadler Wm, Ahmann Fr, Whiteside T, Bizouarne N, Acres B, Limacher Jm, Squiban  P and Pantuck A.
MVA-MUC1-IL2 vaccine immunotherapy (TG4010) improves PSA doubling time in patients with prostate cancer with biochemical failure.
Invest New Drugs (2009), 27, 379-386 >>> READ MORE on

Inchauspe G, Bach G , Martin P and Bonnefoy Jy.
Vaccination against hepatitis B and C: towards therapeutic application.
International Review of Immunology (2009), 28, 7-19 >>> READ MORE on

Tosch C, Geist M, Ledoux C, Ziller-Remi C, Paul S, Erbs P , Corvaia N, Von Hoegen P, Balloul Jm and Haegel H.
Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy
Cancer Gene Therapy (2009), 16, 310-319 >>> READ MORE on

Wooddell Ci, Zhang G, Griffin Jb, Hegge Jo, Huss T and Wolff Jon A.
Use of Evans Blue Dye to compare limb muscles in exercised young and old mdx mice
Muscle Nerve (2009), in press

Zhang G, Wooddell Ci, Hegge Jo, Griffin Jb, Huss T, Braun S and Wolff Jon A.
Functional Efficacy of Dystrophin Expression from Plasmids Delivered to mdx Mice by Hydrodynamic Limb Vein Injection.
Human Gene Therapy (2009), in press

2008

 

Acres B and Bonnefoy  Jy.
Clinical development of MVA-based therapeutic cancer vaccines.
Expert Review Vaccines (2008), 7, 889-893 >>> READ MORE on

Bonnefoy Jy.
The biomarker revolution: a step toward personalized medicine.
Per Med (2008), 5, 553-556 >>> READ MORE on

Dummer R, Rochlitz C, Velu T, Acres B, Limacher Jm, Bleuzen P, Lacoste G, Slos P, Romero P and Urosevic M.
Intralesional adenovirus-mediated interleukin-2 gene transfer for advanced solid cancers and melanoma
Molecular Therapy (2008), 16, 985-994 >>> READ MORE on

Erbs P, Findeli A, Kintz J,  Cordier P, Hoffmann C, Geist M and Balloul Jm.
Modified vaccinia virus Ankara as a vector for suicide gene therapy
Cancer Gene Therapy (2008), 15, 18-28 >>> READ MORE on

Foloppe J, Kintz J, Futin N, Findeli A, Cordier P, Schlesinger Y,  Hoffmann C, Tosch C, Balloul Jm and Erbs P.
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus
Gene Therapy (2008), 15, 1361-71 >>> READ MORE on

Inchauspé G, Honnet G, Bonnefoy Jy, Nicosia A and Strickland Gt.
Hepatitis C vaccine: supply and demand.
Lancet Infectious Diseases (2008), 8, 739-740. >>> READ MORE on

Martin P, Simon B, Lone Yc, Chatel L, Barry R, Inchauspe G and Fournillier A.
A vector-based minigene vaccine approach results in strong induction of T-cell responses specific of hepatitis C virus.
Vaccine (2008), 26, 2471-2481 >>> READ MORE on

Quoix E, Westeel V, Papai Z, Riviere A, Madroszyk A, Koralewski P, Lacoste G, Bizouarne N, Limacher Jm and Ramlau R.
Randomized phase IIb trial evaluating the therapeutic vaccine TG4010 (MVA-MUC1-IL2) as an adjunct to chemotherapy in patients with advanced non-small cell lung cancer (NSCLC).
Annual Oncology Conference (2008), 19, 92 >>> READ MORE on

Ramlau R, Quoix E , Rolski  J, Pless  M, Lena H, Levy E, Krzakowski  M, Hess  D, Tartour  E, Chenard Mp, Limacher Jm, Bizouarne N, Acres B and Velu T.
A Phase II Study of Tg4010 (Mva-Muc1-Il2) in Association with Chemotherapy in Patients with Stage III/IV Non-small Cell Lung Cancer
Journal of Thoraic Oncology (2008), 3, 735-744 >>> READ MORE on

2007

 

Acres B.
Cancer immunotherapy: phase II clinical studies with TG4010 (MVA-MUC1-IL2).
J BUON. (2007), 12, S71-75 >>> READ MORE on

Acres B, Limacher Jm and Bonnefoy Jy
Discovery and Development of Therapeutic Cancer Vaccines
Current Opinion in Drug Discovery Development (2007), 10, 185-192 >>> READ MORE on

Breton E, Choquet  P, Goetz C, Kintz J, Erbs P, Rooke R and Constantinesco A.
Dual SPECT/MR imaging in small animal
Nuclear Instruments & Methods in Physics Research (2007), 571, 446-448 >>> READ MORE on

Fiorucci M, Boulant S, Fournillier A, Abraham Jd, Lavergne Jp, Paranhos-Baccala G, Inchauspe G and Bain C. 
Expression of alternative reading frame protein of hepatitis C virus induces cytokines involved in hepatic injuries.
Journal of General Virololgy (2007), 88, 1149-1162 >>> READ MORE on

Fournillier A, Gerossier E, Evlachev A, Schmitt D, Chatel L, Martin P, Silvestre N, Balloul Jm and Inchauspe G.
An accelerated vaccine schedule with a multivalent hepatitis C virus MVA-based vaccine induces potent, long listing and cross-protective T cell responses.
Vaccine (2007), 25, 7339-7353 >>> READ MORE on

Granio O, Norez C, Ashbourne Excoffon Kj, Karp Ph, Lusky M, Becq F, Boulanger P, Zabner J and Hong Ss.
Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells
American Journal of Respiratory Cell and Molecular Biology (2007), 37, 631-639 >>> READ MORE on

Inchauspé G and Michel  Ml.
Vaccines and immunotherapies against hepatitis B and hepatitis C viruses
Journal of Viral Hepatitis (2007), 14, 97-103 >>> READ MORE on

Limacher  Jm and Acres B.
La Protéine MUC1, cible thérapeutique en oncologie.
Bulletin du Cancer (2007), 94, 253-257>>> READ MORE on and

Paul S, Acres A, Limacher Jm and Bonnefoy Jy.
Cancer vaccines: Challenges and outlook in the field.
IDrugs (2007), 10, 324-328 >>> READ MORE on

Rittner Karola, Schreiber V, Erbs P and Lusky M.
Targeting of adenovirus vectors carrying a tumour-cell specific peptide: in vitro and in vivo studies
Cancer Gene Therapy (2007), 14, 509-518 >>> READ MORE on

Rollier Cs, Paranhos-Baccala G, Verschoor Ej, Verstrepen Be, Drexhage Ja, Fagrouch Z, Berland Jl, Komurian-Pradel F, Duverger B, Himoudi N, Staib C, Meyr M, Whelan M, Whelan Ja, Adams Va, Larrea E, Riezu Ji, Lasarte Jj, Bartosch B, Cosset Fl, Spaan Wj, Diepolder Hm, Pape Gr, Sutter G, Inchauspe G and Heeney Jl.
Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity.
Hepatology (2007), 45, 602-613 >>> READ MORE on

Urosevic M, Fujii K, Calmels B, Laine E, Kobert N, Acres B and Dummer R.
Type I interferon innate response to adenoviral vector contributes to the regression of cutaneous lymphomas following adenovirus-mediated IFN-gamma gene transfer.
Journal of Clinical Investigation (2007), 117, 2834-2846 >>> READ MORE on

Vigen Kk, Hegge Jo, Zhang G, Mukherjee R, Braun S, Grist Tm. and Wolff  Ja.
Magnetic resonance imaging-monitored plasmid DNA delivery in primate limb muscle
Human Gene Therapy (2007), 18, 257-268 >>> READ MORE on

2006

 

Acres B  and Bonnefoy Jy.
Clinical review: Cancer vaccines - The development of cancer vaccines.
Hospital Pharmacy Europe (2006), 1-2 >>> READ MORE on

Fournillier A, Dupeyrot P, Martin P, Parroche P, Pajot A, Chatel L, Fatmi A, Gerossier E, Bain C, Lone Yc, Trepo C and Inchauspe G.
Primary and memory T cell responses induced by hepatitis C virus multiepitope long peptides.
Vaccine (2006), 24, 3153-3164 >>> READ MORE on

Inchauspe G.
HEP DART 2005 - HCV therapeutics
IDrugs (2006), 9, 168-170 >>> READ MORE on

Liu Ma, Wahren B, Karlsson Hedestam Gb.
DNA Vaccines: Recent Developments and Future Possibilities.
Human Gene Therapy (2006), 17, 1051-1061 >>> READ MORE on

Martin P and Inchauspe G.
Hepatitis C vaccines
Drug Discovery Today: Therapeutic Strategies  (2006), 3 , 203-209 >>> READ MORE on

Martin P, Parroche P, Pajot A, Chatel L, Barreto C, Touat L, Dubois V, Rohrlich Ps, Bain C, Trepo C, Negro F, Inchauspe G and Fournillier A.
Optimized vaccination regimen linked to exhaustive screening approaches identifies 2 novel HLA-B7 restricted epitopes within hepatitis C virus NS3 protein.
Microbes and Infection (2006), 8, 2432-2441 >>> READ MORE on

Ulmer Jb., Wahren B and Liu Ma.
Gene-based vaccines: recent technical and clinical advances.
Trends in Molecular Medicine (2006), 12, 216-222 >>> READ MORE on

Urosevic M, Gellrich S, Dreno B, Schiller M, Dereure O, Baudard M, Bagot M, Khammari A, Bleuzen P and Dummer R.
Adenovirus-interferon (TG1042) demonstrates good tolerance and efficacy in relapsing primary cutaneous lymphoma (PCL): Final results of a phase I/II multicentric trial.
Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings (June 20 Supplement), 24, 7359 >>> READ MORE on

2005

 

Acres B, Gantzer M, Remy C, Futin N, Accart N, Chaloin O, Hoebeke J, Balloul Jm and Paul S
Fusokine interleukin-2/interleukin-18, a novel potent innate and adaptive immune stimulator with decreased toxicity
Cancer Research (2005), 65, 9536-9546 >>> READ MORE on and

Acres B and Limacher Jm.
MUC1 as a target antigen for cancer immunotherapy
Expert Review of Vaccines (2005), 4, 493-502 >>> READ MORE on

Acres B, Squiban P and Liu M.
Gene-based Cancer Immunotherapy and Vaccines
Discovery Medicine (2005), 5, 25-29

Becard N, De Revel T, Sorg T, Dormont D and Le Grand R.
Expression of human IL-1alpha after intramarrow gene transfer into healthy non-human primate by adenoviral vector
Journal of Medical Primatology (2005), 34, 1-12 >>> READ MORE on

Britta W and Liu M.
DNA Vaccines - An overview.
in: "DNA Pharmaceutical: Formulation and Delivery in Gene Therapy"  (2005 ),  Martin Schleef , Ed),  Wiley-VCH Verlag GmbH & Co. KGaA,  Weinheim,  pp. 1-6 >>> READ MORE on and

Calmels B, Paul S, Ziller C and Acres B
Secretomers as a new tool for the monitoring of CTL responses
Cancer Immunology & Immunotherapy (2005), 54, 548-556 >>> READ MORE on

Cauet G, Strub Jm , Leize E, Wagner E, Van Dorsselaer A and Lusky M.
Identification of the glycosylation site of the adenovirus type 5 fiber protein
Running Title : Adenovirus Fiber Glycosylation Biochemistry (2005), 44, 5453-5460 >>> READ MORE on

Donnelly John J, Wahren Britta and Liu  Ma
DNA Vaccines: Progress and Challenges.
Journal of Immunology (2005), 175, 633-639 >>> READ MORE on

Dreicer R, Ahman R, Pantuck A, Stadler Wm, Bizouarne N, Acres B, Derbij A, Limacher Jm and Squiban P.
Vaccine immunotherapy with MVA-MUC1-IL2 (TG4010) in prostate cancer patients with biochemical failure
Journal of Clinical Oncology (2005), 23, 4518 >>> READ MORE on and

Dreicer R, Stadler  Wm, Ahman R, Whiteside  T, Bizouarne N, Acres B, Limacher Jm, Squiban P and Pantuck A.
MVA-MUC1-IL2 Vaccine Immunotherapy (TG4010) improves PSA doubling time in patients with prostate cancer with biochemical failure.
Journal of Clinical Oncology (2005) Prostate Cancer Symposium

Fardeau M, Braun S, Romero Nb, Hogrel Jy, Rouche A, Ortega V, Mourot B, Squiban P, Benveniste O and Herson S.
"About a phase I gene therapy clinical trial with a full-length dystrophin gene-plasmid in Duchenne/ Becker muscular dystrophy" (French)
Journal de la Société de Biologie  (2005), 1999, 29-32>>> READ MORE on

GOURC D, BOUGARET S and BURTIN B.
Un modele d'évaluation de la rentabilité des projets incertains utilisant la simulation Monte Carlo : application a un projet de médicament.
Congres QUALITA, Bordeaux, 16-18 mars 2005 (2005), Bordeaux, 16-18 mars >>> READ MORE on

Kamath At, Fruth U, Brennan Mj, Dobbelaer R, Hubrechts P, Ho Mm, Mayner Re, Thole J, Walker Kb, Liu M, Lambert Ph, Aeras Global Tb Vaccine Foundation and World Health Organization.
New live mycobacterial vaccines: the Geneva consensus on essential steps towards clinical development.
Vaccine (2005), 23, 3753-3761 >>> READ MORE on

Lambert P H, Liu M and Siegrist Ca.
Can successful vaccines teach us how to induce efficient protective immune responses?
Nature Medicine (2005), 11, S54-62 >>> READ MORE on

Linassier C, Oudard S, Rixe O, Machiels Jp, Rossi Jf, Ringeisen F, Velu T, Banu E, Acres B and Squiban P.
Phase II study of the cancer vaccine TG4010 in metastatic renal cell carcinoma.
Journal of Clinical Oncology (2005), 23, 4653 >>> READ MORE on

Liu Ma and Ulmer Jb.
Human clinical trials of plasmid DNA vaccines
Advances in Genetics (2005), 55, 25-40 >>> READ MORE on

Lusky M
Good manufacturing practice production of adenoviral vectors for clinical trials.
Human Gene Therapy (2005), 16, 281-291 >>> READ MORE on

Menu E, Muller-Trutwin Mc, Pancino G, Saez-Cirion A, Bain C, Inchauspe G, Gras Gs, Mabondzo Am, Samri A, Boutboul F and Le Grand R.
First Dominique Dormont International Conference on "Host-pathogen interactions in chronic infections - viral and host determinants of HCV, HCMV, and HIV infections".
Retrovirology (2005), 2, 24 >>> READ MORE on

Nattermann J, Schneiders Am, Leifeld L, Langhans B, Schulz M, Inchauspe G, Matz B, Brackmann Hh, Houghton M, Sauerbruch T and Spengler U.
Serum antibodies against the hepatitis C virus E2 protein mediate antibody-dependent cellular cytotoxicity (ADCC)
Journal of Hepatology (2005), 42, 499-504 >>> READ MORE on

Rollier C, Verschoor Ej, Paranhos-Baccala G, Drexhage Ja, Verstrepen Be, Berland Jl, Himoudi N, Barnfield C, Liljestrom P, Lasarte Jj, Ruiz J, Inchauspe G and Heeney Jl.
Modulation of vaccine-induced immune responses to hepatitis C virus in rhesus macaques by altering priming before adenovirus boosting
Journal of Infectious Diseases (2005), 192, 920-929. >>> READ MORE on

Simmonds P, Bukh J, Combet C, Deleage G, Enomoto N, Feinstone S, Halfon P, Inchauspe G, Kuiken C, Maertens G, Mizokami M, Murphy Dg, Okamoto H, Pawlotsky Jm, Penin F, Sablon E, Shin-I T, Stuyver Lj, Thiel Hj, Viazov S, Weiner Aj and Widell A.
Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
Hepatology (2005), 42, 962-973 >>> READ MORE on

Velu T , Ramlau R, Quoix E,  Pawlicki M, Pless M, Lena H, Lévy E, Krzakowski M, Limacher Jm and Bizouarne M.
A phase II study evaluating the clinical efficacy of TG4010 (MVA-MUC1-IL2) in association with chemotherapy in patients with non small cell lung cancer
Journal of Clinical Oncology (2005), 23, 7132 >>> READ MORE on and

2004

 

Acres B, Paul S, Haegel-Kronenberger H, Calmels B and Squiban P.
Therapeutic cancer vaccines
Current Opinion in Molecular Therapeutics (2004), 6, 40-47 >>> READ MORE on

Alam A, Herault Jp, Barron P, Favier B, Fons P, Delesque-Touchard N, Senegas I, Laboudie P, Bonnin J, Cassan C, Savi P, Ruggeri B, Carmeliet P, Bono F and Herbert Jm.
Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activity.
Biochemical and Biophysical Research Communication (2004), 324, 909-915 >>> READ MORE on

Aleman S, Leitner T, Liu Ma and Wahren B.
Minor nef gene alterations after human HIV-DNA immunisation
AIDS (2004), 18, 817-819 >>> READ MORE on

Calmels B.
Immunologie et cancer. 1ère partie: réponse immunitaire antitumorale.
Oncologie  (2004), 6, 467-478 >>> READ MORE on

Calmels B.
Immunologie et cancer : mécanismes d'échappement tumoraux.
Oncologie  (2004), 6, 525-533 >>> READ MORE on

Ceraline J, Cruchant Md, Erdmann E, Erbs P, Kurtz Je, Duclos B, Jacqmin D, Chopin D and Bergerat Jp.
Constitutive activation of the androgen receptor by a point mutation in the hinge region: a new mechanism for androgen-independent growth in prostate cancer.
International Journal of Cancer (2004), 108, 152-157 >>> READ MORE on

Dummer R, Hassel Jc, Fellenberg F, Eichmuller S, Maier T, Slos P, Acres B, Bleuzen P, Bataille V, Squiban P, Burg G and Urosevic M.
Adenovirus-mediated intralesional interferon-gamma gene transfer induces tumor regressions incutaneous lymphomas.
Blood (2004), 104, 1631-1638 >>> READ MORE on

Dummer R, Squiban P, Bleuzen P, Acres B, Eichmueller S and Urosevic M.
Adenovirus Mediated Interferon-gamma Expression in Cutaneous Lymphoma: Monitoring of Local and Systemic Events.
Journal of Immunotherapy (2004), 27, S40 Journal of Immunotherapy

Haegel-Kronenberger H,  Haanstra K, Ziller-Remy C, Ortiz Buijsse Ap, Vermeiren J, Stoeckel F, Van Gool S W, Ceuppens J L, Mehtali M, De Boer M, Jonker M and Boon L.
Inhibition of costimulation allows for repeated systemic administration of adenoviral vector in rhesus monkeys.
Gene Therapy (2004), 11, 241-252 >>> READ MORE on

Hensen K, Braem C, Declercq J, Van Dyck F, Dewerchin M, Fiette L, Denef C and Van De Ven Wj.
Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility.
Dev Growth Differ.  (2004), 46, 459-470 >>> READ MORE on

Hillman Gg, Slos P, Wang Y, Wright Jl, Layer A, De Meyer M, Yudelev M, Che M X and Forman Jd.
Tumor irradiation followed by intratumoral cytokine gene therapy for murine renal adenocarcinoma.
Cancer Gene Therapy (2004), 11, 61-72 >>> READ MORE on

Isaguliants Mg, Zuber B, Boberg A, Sjostrand D, Belikov Sv, Rollman E, Zuber Ak, Rechinsky Vo, Rytting As, Kallander Cf, Hinkula J, Kochetkov Sn, Liu M and Wahren R.
Reverse transcriptase-based DNA vaccines against drug-resistant HIV-1 tested in a mouse model.
Vaccine (2004), 22, 1810-1819 >>> READ MORE on

Liu M, Acres B, Balloul Jm, Bizouarne N, Paul S, Slos P and Squiban P.
Gene-based vaccines and immunotherapeutics
Proceedings of the National Academy of Science Natl Ac (2004), 101, 14567-14571 >>> READ MORE on

Liu Ma.
DNA Vaccines
in: "New Generation Vaccines, 3rd Edition"  (2004),  Levine Mm, Kaper Jb, Rappuoli R, Liu Ma, Good Mf, Eds),  Marcel Dekker, Inc,  New York - Basel,  pp. 367-379. >>> READ MORE on

Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Breant C, Claes F, De Smet F, Thomas Jl, Autiero M, Carmeliet P, Tessier-Lavigne M and Eichmann A.
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system.
Nature (2004), 432, 179-186 >>> READ MORE on

Marchand E, Constantin B, Balghi H, Claudepierre Mc, Cantereau A, Magaud C, Mouzou A, Raymond G, Braun S and Cognard C.
Improvement of calcium handling and changes in calcium-release properties after mini- or full-length dystrophin forced expression in cultured skeletal myotubes.
Experimental Cell Research (2004), 297, 363-379 >>> READ MORE on

Pantuck Aj, Van Ophoven A, Gitlitz Bj, Tso Cl, Acres B, Squiban P, Ross Me, Belldegrun As and Figlin Ra
Phase I trial of antigen-specific gene therapy using a recombinant vaccinia virus encoding MUC-1 and IL-2 in MUC-1-positive patients with advanced prostate cancer.
Journal of Immunotherapy (2004), 27, 240-253 >>> READ MORE on

Rollman E, Hinkula J, Arteaga J, Zuber B, Kjerrstrom A, Liu M, Wahren B and Ljungberg K.
Multi-subtype gp160 DNA immunization induces broadly neutralizing anti-HIV antibodies.
Gene Therapy (2004), 11, 1146-1154 >>> READ MORE on

Romero Nb , Braun S, Benveniste O, Leturcq F, Hogrel Jy, Morris Ge, Barois A, Eymard B, Payan  C, Ortega V, Boch  Al, Lejean  Lise, Thioudellet C, Mourot B, Escot C, Choquel A, Recan  D, Kaplan Jc, Dickson  G, Klatzmann D, Molinier-Frenckel V, Guillet  Jg, Squiban  P, Herson S and Fardeau M.
Phase I study of dystrophin plasmid-based gene therapy in Duchenne/Becker muscular dystrophy.
Human Gene Therapy (2004), 15, 1065-1076 >>> READ MORE on

Settelen N, Roch O, Bock D, Rooke R, Braun S and Meyer O.
Controlled plasmid gene transfer to murine renal carcinoma by hexadecylphosphocholine
Journal of Controlled Release (2004), 94,  237-244 >>> READ MORE on

Slos P and Erbs P.
Intratumoral delivery of genes: a new weapon against cancer?
Expert Review of Anticancer Therapy (2004), 4, 493-495 >>> READ MORE on

Squiban P, Velu T, Mennecier B, Pless M, Morel V, Levy E, Richard V, Maciejewska T, Bizouarne N and Quoix E.
MVA-MUC1-IL2 vaccine immunotherapy for advanced non small cell lung cancer (NSCLC): Interim phase II data.
Journal of Clinical Oncology (2004), 22, 2544. >>> READ MORE on

Urosevic M, Bleuzen P, Acres B, Bataille V, Slos P, Burg G, Squiban P and Dummer R.
Phase I/II study of adenovirus-interferon- (TG1042) in primary cutaneous lymphomas (CL) .
Journal of Clinical Oncology, 2004 ASCO Annual Meeting Proceedings (2004), 22, 3039
2004 ASCO Annual Meeting Proceedings, Abstract No: 3039 >>> READ MORE on and

Vermeiren J, Ceuppens Jl, Haegel-Kronenberger H, De Boer M, Boon L and Van Gool Sw.
Blocking B7 and CD40 co-stimulatory molecules decreases antiviral T cell activity
Clinical and Experimental Immunology (2004), 135, 253-258 >>> READ MORE on

Wahren B and Liu M.
Therapeutic vaccination against HIV
Expert Review of Vaccines (2004), 3, S179-188 >>> READ MORE on

Zhang Gf, Ludtke Jj, Thioudellet C, Kleinpeter P, Antoniou M, Herweijer H, Braun S and Wolff Ja.
Intraarterial delivery of naked plasmid DNA expressing full-length mouse dystrophin in the mdx mouse model of duchenne muscular dystrophy..
Human Gene Therapy (2004), 15, 770-782 >>> READ MORE on

2003

 

CERALINE J, ERDMANN E, ERBS P, DESLANDRES-CRUCHANT M, JACQMIN D, DUCLOS B, KLEIN-SOYER C, DUFOUR P and BERGERAT JP
A Yeast-Based Functional Assay for the Detection of the Mutant Androgen Receptor in Prostate
Cancer.
European Journal of Endocrinology (2003), 148, 99-109.

FRAULI M, RIBAULT S, NEUVILLE P, AUGE F and CALENDA V
Adenoviral-mediated skeletal muscle transcriptional targeting using chimeric tissue-specific
promoters.
Medical Science Monitor (2003), 9, BR78-84.

GRISCELLI F, OPOLON P, SAULNIER P, MAMI-CHOUAIB F, GAUTIER E, ECHCHAKIR H, ANGEVIN E, LE CHEVALIER T, BATAILLE V, SQUIBAN P, TURSZ T and ESCUDIER B
Recombinant Adenovirus Shedding After Intratumoral Gene Transfer in Lung Cancer Patients.
Gene Therapy (2003), 10, 386-395.

HILLMAN GG, KALLINTERIS NL, LI J, WANG Y, LU X, LI Y, WU S, WRIGHT JL, SLOS P, GULFO JV, HUMPHREYS RE and XU M
Generating Mhc Class Ii+/Ii- Phenotype After Adenoviral Delivery of Both an Expressible Gene
for Mhc Class Ii Inducer and an Antisense Ii-Rna Construct in Tumor Cells.
Gene Therapy (2003), 10, 1512-1518.

KELLERMAN LC, VALEYRIE L, FERNANDEZ N, OPOLON P, SABOURIN JC, MAUBEC E, LE ROY P, KANE A, LEGRAND A, ABINA MA, DESCAMPS V and HADDADA H
Regression of Ak7 Malignant Mesothelioma Established in Immunocompetent Mice Following
Intratumoral Gene Transfer of Interferon Gamma.
Cancer Gene Therapy (2003), 10, 481-490.

KHORANA AA, ROSENBLATT JD, SAHASRABUDHE DM, EVANS T, LADRIGAN M, MARQUIS D, ROSELL K, WHITESIDE T, PHILLIPPE S, ACRES B, SLOS P, SQUIBAN P, ROSS M and KENDRA K
A phase I trial of immunotherapy with intratumoral adenovirus-interferon-gamma (TG1041) in
patients with malignant melanoma.
Cancer Gene Therapy (2003), 10, 251-259.

LIU MA
Dna Vaccines: a Review.
Journal of Internal Medicine (2003), 253, 402-410.

PAUL S
Technology evaluation: CpG-7909, Coley.
Current Opinion in Molecular Therapeutics (2003), 5, 553-9.

RITTNER K, BENAVENTE A and JACOBS E
Ligation of Exogenous Linear Dna After Gene Transfer in Vitro and in Vivo.
Journal of Gene Medicine (2003), 5, 818-824.

ROCHLITZ C, FIGLIN R, SQUIBAN P, SALZBERG M, PLESS M, HERRMANN R, TARTOUR E, ZHAO YX, BIZOUARNE N, BAUDIN M and ACRES B
Phase I Immunotherapy With a Modified Vaccinia Virus (Mva) Expressing Human Muc1 as
Antigen-Specific Immunotherapy in Patients With Muc1-Positive Advanced Cancer.
Journal of Gene Medicine (2003), 5, 690-699.

ROSA-CALATRAVA M, PUVION-DUTILLEUL F, LUTZ P, DREYER D, DE THE H, CHATTON B and KEDINGER C
Adenovirus Protein Ix Sequesters Host-Cell Promyelocytic Leukaemia Protein and Contributes
to Efficient Viral Proliferation.
Embo Reports (2003), 4, 969-975.

SCHOLL S, SQUIBAN P, BIZOUARNE N, BAUDIN M, ACRES B, VON MENSDORFFPOUILLY S, SHEARER M, BEUZEBOC P, VAN BELLE S, UZIELLY B, POUILLART P, TAYLOR-PAPADIMITRIOU J and MILES D
Metastatic Breast Tumour Regression Following Treatment by a Gene-Modified Vaccinia Virus
Expressing MUC1 and IL-2.
J Biomed Biotechnol (2003), 2003, 194-201.

SIGRIST S, MECHINE-NEUVILLE A, MANDES K, CALENDA V, BRAUN S, LEGEAY G, BELLOCQ JP, PINGET A and KESSLER L
Influence of Vegf on the Viability of Encapsulated Pancreatic Rat Islets After Transplantation in
Diabetic Mice.
Cell Transplantation (2003), 12, 627-635.

SIGRIST S, MECHINE-NEUVILLE A, MANDES K, CALENDA V, LEGEAY G, BELLOCQ JP, PINGET M and KESSLER L
Induction of Angiogenesis in Omentum With Vascular Endothelial Growth Factor: Influence on
the Viability of Encapsulated Rat Pancreatic Islets During Transplantation.
Journal of Vascular Research (2003), 40, 359-367.

SCHUGHART K and ACCART N
Use of Adenovirus Vectors for Functional Gene Analysis in the Chicken Chorioallantoic Membrane.
Biotechniques (2003), 34, 178-183.

SRIVASTAVA IK and LIU MA
Gene Vaccines.
Annals of Internal Medicine (2003), 138, 550-559.

SZCZEBARA FM, CHANDELIER C, VILLERET C, MASUREL A, BOUROT S, DUPORT C, BLANCHARD S, GROISILLIER A, TESTET E, COSTAGLIOLI P, CAUET G, DEGRYSE E, BALBUENA D, WINTER J, ACHSTETTER T, SPAGNOLI R, POMPON D and DUMAS B
Total Biosynthesis of Hydrocortisone From a Simple Carbon Source in Yeast.
Nature Biotechnology (2003), 21, 143-149.

2002

 

ACRES B, BEVERLEY P and SCHOLL S
Tumor Immunology and the Battle of Waterloo.
Molecular Cancer Therapeutics (2002), 1, 651-655.

BRAUN S and ROMERO N
Special Centennial Workshop - 101st ENMC International Workshop: Therapeutic Possibilities
in Duchenne Muscular Dystrophy.
Neuromuscular Disorders (2002), 12, 421-431.

DE REVEL T, BECARD N, SORG T, ROUSSEAU S, SPANO JP, THIEBOT H, METHALI M, GRAS G, LE GRAND R and DORMONT D
Retroviral Interleukin 1 Alpha Gene Transfer in Bone Marrow Stromal Cells in a Primate
Model: Induction of Myelopoiesis Stimulation.
British Journal of Haematology (2002), 118, 875-884.

FATACCIOLI V, ABERGEL V, WINGERTSMANN L, NEUVILLE P, SPITZ E, ADNOT S, CALENDA V and TEIGER E
Stimulation of Angiogenesis by Cyr61 Gene: a New Therapeutic Candidate.
Human Gene Ther (2002), 13, 1461-1470.

GADEN F, FRANQUEVILLE L, HONG SS, LEGRAND V, FIGARELLA C and BOULANGER P
Mechanism of Restriction of Normal and Cystic Fibrosis Transmembrane Conductance egulator-Deficient Human Tracheal Gland Cells to Adenovirus Infection and Ad-Mediated
Gene Transfer.
American Journal of Respiratory Cell and Molecular Biology (2002), 27, 628-640.

GANTZER M, SPITZ E, ACCARD N and ROOKE R
Constitutive Expression of the Adenovirus E3-14.7K Protein Does Not Prolong Adenovirus ector DNA Persistence but Protects Mice Against Lipopolysaccharide-Induced Acute
Hepatitis.
Human Gene Ther (2002), 13, 921-933.

GUO J, WANG B, ZHANG M, CHEN T, YU Y, REGULIER E, HOMANN HE, QIN Z, JU DW and CAO X
Macrophage-derived chemokine gene transfer results in tumor regression in murine lung carcinoma model through efficient induction of antitumor immunity .
Gene Ther (2002), 9, 793-803.

LE BON B, VAN CRAYNEST N, BOUSSIF O and VIERLING P
Polycationic Diblock and Random Polyethylene Glycol- or Tris(Hydroxymethyl)Methyl-Grafted (Co)Telomers for Gene Transfer: Synthesis and Evaluation of Their in Vitro Transfection Efficiency.
Bioconjugate Chemistry (2002), 13, 1292-1301.

LEGRAND V, LEISSNER P, WINTER A, MEHTALI M and LUSKY M
Transductional targeting with recombinant adenovirus vectors.
Current Gene Therapy (2002), 2, 323-39.

TRANSGENE – November 2008 10/13 LUSKY M, DEGRYSE E, MEHTALI M and CHARTIER C
Adenoviral vector construction II: bacterial systems.
in: "Adenoviral Vectors for Gene Therapy" (2002), (DT Curiel and J.T.Douglas, eds), Academic Press, San Diego, USA, pp. 105-127.

PAUL S, CAMELS B and ACRES B
Improvement of adoptive cellular immunotherapy of human cancer using ex-vivo gene transfer.
Curr Gene Ther (2002), 2, 91-100.

PAUL S and REGULIER E
[Cancer genetic immunotherapy].
Transfusion Clinique et Biologique (2002), 9, 301-21.

PAUL S, REGULIER E, POITEVIN Y, HORMANN H and ACRES RB
The Combination of a Chemokine, Cytokine and Tcr-Based T Cell Stimulus for Effective Gene
Therapy of Cancer.
Cancer Immunology Immunotherapy (2002), 51, 645-654.

PAUL S, REGULIER E, ROOKE R, STOECKEL F, GEIST M, HOMANN H, BALLOUL JM, VILLEVAL D, POITEVIN Y, KIENY MP and ACRES RB
Tumor gene therapy by MVA-mediated expression of T-eell-stimulating antibodies .
Cancer Gene Ther (2002), 9, 470-477.

RASMUSSEN UB, SCHREIBER V, SCHULTZ H, MISCHLER F and SCHUGHART K
Tumor cell-targeting by phage-displayed peptides.
Cancer Gene Ther (2002), 9, 606-612.

RAYKOV Z, LEGRAND V, HOMANN HE and ROMMELAERE J
Transient Suppression of Transgene Expression by Means of Antisense Oligonucleotides: a Method for the Production of Toxin-Transducing Recombinant Viruses.
Gene Ther (2002), 9, 358-362.

REIX P, BELLON G, BIENVENU J, PAVIRANI A and LEVREY-HADDEN N
Cytokine Pattern in Cystic Fibrosis Patients During Antibiotic Therapy and Gene Therapy Using Adenoviral Vector.
European Cytokine Network (2002), 13, 324-330.

RITTNER K, BENAVENTE A, BOMPARD-SORLET A, HEITZ F, DIVITA G, BRASSEUR R and JACOBS E
New basic membrane-destabilizing peptides for plasmid-based gene delivery in vitro and in vivo.
Mol Ther (2002), 5, 104-114.

ROCHLITZ C, DRENO B, JANTSCHEFF P, CAVALLI F, SQUIBAN P, ACRES B, BAUDIN M, ESCUDIER B, HEINZERLING L, MORANT R, HERRMANN R, DIETRICH PY and DUMMER R
Immunotherapy of Metastatic Melanoma by Intratumoral Injections of Vero Cells Producing Human Il-2: Phase II Randomized Study Comparing Two Dose Levels.
Cancer Gene Ther (2002), 9, 289-295.

ROMERO NB, BENVENISTE O, PAYAN C, BRAUN S, SQUIBAN P, HERSON S and FARDEAUM
Current Protocol of a Research Phase I Clinical Trial of Full-Length Dystrophin Plasmid Dna in Duchenne/Becker Muscular Dystrophies - Part Ii: Clinical Protocol.
Neuromuscular Disorders (2002), 12, S45-S48.

SCHUGHART K and RASMUSSEN UB
Solvoplex Synthetic Vector for Intrapulmonary Gene Delivery.
in: "Gene therapy protocols" (2002), 69, (J.R. Morgan ed.), Humana Press Inc., Totowa, NJ, pp. 83-94.

SOUQUERE-BESSE S, PICHARD E, FILHOL O, LEGRAND V, ROSA-CALATRAVA M, HOVANESSIAN AG, COCHET C and PUVION-DUTILLEUL F
Adenovirus Infection Targets the Cellular Protein Kinase Ck2 and Rna-Activated Protein
Kinase (Pkr) Into Viral Inclusions of the Cell Nucleus.
Microscopy Research and Technique (2002), 56, 465-478.

THIOUDELLET C, BLOT S, SQUIBAN P, FARDEAU M and BRAUN S
Current Protocol of a Research Phase I Clinical Trial of Full-Length Dystrophin Plasmid Dna in
Duchenne/Becker Muscular Dystrophies - Part I: Rationale.
Neuromuscular Disorders (2002), 12, S49-S51.

ULMER JEFFREY B. and LIU MARGARET A.
Ethical issues for vaccines and immunization
Nature Reviews Immunology (2002), 2, 291-296.

VAN CRAYNEST N, SANTAELLA C, BOUSSIF O and VIERLING P
Polycationic Telomers and Cotelomers for Gene Transfer: Synthesis and Evaluation of Their in
Vitro Transfection Efficiency.
Bioconjugate Chemistry (2002), 13, 59-75.

VAN LINTHOUT S, LUSKY M, COLLEN D and DE GEEST B
Persistent Hepatic Expression of Human Apo a-I After Transfer With a Helper-Virus
Independent Adenoviral Vector.
Gene Therapy (2002), 9, 1520-1528.

ZALOUDIK J, LI WP, JACOB L, KIENY MP, SOMASUNDARAM R, ACRES B, SONG H, ZHANG TQ, LI J and HERLYN D
Inhibition of tumor growth by recombinant vaccinia virus expressing GA733/CO17-
1A/EpCAM/KSA/KS1-4 antigen in mice.
Cancer Gene Ther (2002), 9, 382-389.

ZILLER C, STOECKEL F, BOON L and HAEGEL-KRONENBERGER H Transient blocking of both B7.1 (CD80) and B7.2 (CD86) in addition to CD40-CD40L
interaction fully abrogates the immune response following systemic injection of adenovirus
vector .
Gene Ther (2002), 9, 537-546.

2001

 

BARATIN M, ZIOL M, ROMIEU R, KAYIBANDA M, GOUILLEUX F, BRIAND P, LEROY P, HADDADA H, RENIA L, VIGUIER M and GUILLET JG
Regression of primary hepatocarcinoma in cancer-prone transgenic mice by local Interferongamma
delivery is associated with macrophages recruitment and nitric oxide production.
Cancer Gene Ther (2001), 8, 193-202.

BENAMMAR-CECCOLI S, HUMBLOT S, CROUZIER R, ACRES B, KIENY MP, HERLYN D, PASQUALI JL and MARTIN T
Recombinant vaccinia viruses expressing immunoglobulin variable regions efficiently and
selectively protect mice against tumoral B-cell growth.
Cancer Gene Ther (2001), 8, 815-826.

BOUSSIF O, GAUCHERON J, BOULANGER C , SANTAELLA C, KOLBE HVJ and VIERLING P
Enhanced in vitro and in vivo cationic lipid-mediated gene delivery with a fluorinated
glycerophosphoethanolamine helper lipid.
Journal of Gene Medicine (2001), 3, 109-114.

GAUCHERON J, BOULANGER C, SANTAELLA C, SBIRRAZZUOLI N, BOUSSIF O and VIERLING P
In vitro cationic lipid-mediated gene delivery with fluorinated glycerophosphoethanolamine
helper lipids.
Bioconjugate Chemistry (2001), 12, 949-963.

GUETTIER-SIGRIST S, COUPIN G, BRAUN S, ROGOVITZ D, COURDIER I, WARTER J M and POINDRON P
On the Possible Role of Muscle in the Pathogenesis of Spinal Muscular Atrophy.
Fundamental & Clinical Pharmacology (2001), 15, 31-40.

JORNOT L, PETERSEN H, LUSKY M, PAVIRANI A, MOIX I, MORRIS M A and ROCHAT T
Effects of first generation E1E3-deleted and second generation E1E3E4-deleted/modified adenovirus vectors on human endothelial cell death.
Endothelium-New York (2001), 8, 167-179.

KARSTEN V, SIGRIST S, MORISCOT C, SORG T, LEMARCHAND P, BELCOURT A, BENHAMOU PY, PINGET M and KESSLER L
How can adenovirus-mediated catalase and superoxide dismutase gene transfer improve the
outcome of pancreatic cells for transplantation ?
Transplant Proc (2001), 33, 575-576.

LEISSNER P, LEGRAND V, SCHLESINGER Y, HADJI-D-A, VAN RAAIJ M, CUSACK S, PAVIRANI A and MEHTALI M
Influence of adenoviral fiber mutations on viral encapsidation, infectivity and in vivo tropism.
Gene Ther. (2001), 8, 49-57.

LERONDEL S, LE PAPE A, SENÉ C, FAURE L, BERNARD S, DIOT P, NICOLIS E, MEHTALI M, LUSKY M, CABRINI G and PAVIRANI A
Radioisotopic imaging allows optimization of adenovirus lung deposition for cystic fibrosis gene therapy.
Hum Gene Ther. (2001), 12, 1-11.

LERONDEL S, VECELLIO NONE L, FAURE L, SIZARET PY, SENE C, PAVIRANI A, DIOT P, LE PAPE A.
Gene therapy for cystic fibrosis with aerosolized adenovirus-CFTR: characterization of the aerosol and scintigraphic determination of lung deposition in baboons.
Journal of Aerosol Medicine (2001), 14, 95-105.

MELOTTI P, NICOLIS E, TAMANINI A, ROLFINI R, PAVIRANI A and CABRINI G
Activation of Nf-Kappa B mediates Icam-1 induction in respiratory cells exposed to an adenovirus-derived vector.
Gene Ther (2001), 8, 1436-1442.

PAUL S and REGULIER E
Bases moléculaires de l'oncogenèse.
Ann Biol Clin (2001), 59, 393-402.

TRANSGENE – November 2008 13/13 PAUL S and REGULIER E
Vecteurs viraux pur la thérapie génique du cancer.
Virologie (2001), 5, 53-69

RIBAULT S, NEUVILLE P, MÉCHINE-NEUVILLE A, AUGÉ F, PARLAKIAN A, GABBIANI G, PAULIN D and CALENDA V
Chimeric Smooth Muscle-Specific Enhancer Promoters: Valuable Tools for Adenovirus-Mediated Cardiovascular Gene Therapy.
Circulation Research (2001), 88, 468-475.

ROITSCH C, ACHSTETTER T, BENCHAIBI M, BONFILS E, CAUET G, GLOECKLER R, L'HOTE H, KEPPI E, NGUYEN M, SPEHNER D, VAN DORSSELAER A and MALARME D
Characterization and quality control of recombinant adenovirus vectors for gene therapy.
J. Chromatogr B (2001), 752, 263-280.

ROSA-CALATRAVA M, GRAVE L, PUVION-DUTILLEUL F, CHATTON B and KEDINGER C
Functional analysis of adenovirus protein IX identifies domains involved in capsid stability, transcriptional activity, and nuclear reorganization.
J Virol (2001), 75, 7131-7141.

SLOS P, DE MEYER M, LEROY P, ROUSSEAU C and ACRES B
Immunotherapy of established tumors in mice by intra-tumoral injection of an adenovirus vector harboring the human IL-2 cDNA: induction of CD8+ T-cell immunity and NK activity.
Cancer Gene Therapy (2001), 8, 321-332.

TREVOR KT, HERSH EM, BRAILEY J, BALLOUL JM and ACRES B
Transduction of human dendritic cells with a recombinant modified vaccinia Ankara virus encoding MUC1 and IL-2.
Cancer Immunol Immunother. (2001), 50, 397-407.